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Title: Boron neutron capture therapy for oral precancer: proof of principle in an experimental animal model

Field-cancerized tissue can give rise to second primary tumours, causing therapeutic failure. Boron neutron capture therapy (BNCT) is based on biological targeting and would serve to treat undetectable foci of malignant transformation. The aim of this study was to optimize BNCT for the integral treatment for oral cancer, with particular emphasis on the inhibitory effect on tumour development originating in precancerous conditions, and radiotoxicity of different BNCT protocols in a hamster cheek pouch oral precancer model.
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Publication Date:
OSTI Identifier:
Report Number(s):
Journal ID: ISSN 1354-523X
DOE Contract Number:
Resource Type:
Journal Article
Resource Relation:
Journal Name: Oral Diseases; Journal Volume: 19; Journal Issue: 8
Research Org:
Idaho National Laboratory (INL)
Sponsoring Org:
Country of Publication:
United States
99 GENERAL AND MISCELLANEOUS boron neutron capture therapy; field cancerization; hamster cheek pouch oral precancer model; oral cancer; precancerous conditions