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Title: Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules

Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distince forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups.
Authors:
; ;
Publication Date:
OSTI Identifier:
1117679
Report Number(s):
8,628,977
12/990,560
DOE Contract Number:
FC36-07GO17059
Resource Type:
Patent
Research Org:
Purdue Research Foundation, West Lafayette, IN, USA
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY