Compositions and methods for adoptive and active immunotherapy

Fahmy, Tarek; Steenblock, Erin

Title: Compositions and methods for adoptive and active immunotherapy

Patent · Tue Jan 14 00:00:00 EST 2014

OSTI ID:1117675

Fahmy, Tarek; Steenblock, Erin

Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents which modularly couple functional elements including T cell receptor activators, co-stimulatory molecules and adhesion molecules to the particle. The ability of these aAPCs to release cytokines in a controlled manner, coupled with their modular nature and ease of ligand attachment, results in an ideal, tunable APC capable of stimulating and expanding primary T cells.

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Research Organization:: ORISE (Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States))

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-06OR23100

Assignee:: Yale University (New Haven, CT)

Patent Number(s):: 8,629,098

Application Number:: 12/812,304

OSTI ID:: 1117675

Resource Relation:: Patent File Date: 2009 Jul 30

Country of Publication:: United States

Language:: English

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