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Title: Compositions and methods for adoptive and active immunotherapy

Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents which modularly couple functional elements including T cell receptor activators, co-stimulatory molecules and adhesion molecules to the particle. The ability of these aAPCs to release cytokines in a controlled manner, coupled with their modular nature and ease of ligand attachment, results in an ideal, tunable APC capable of stimulating and expanding primary T cells.
Authors:
;
Publication Date:
OSTI Identifier:
1117675
Report Number(s):
8,629,098
12/812,304
DOE Contract Number:
AC05-06OR23100
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009 Jul 30
Research Org:
ORISE (Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States))
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES