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Title: Genetically modified yeast species, and fermentation processes using genetically modified yeast

Patent ·
OSTI ID:1113979
 [1];  [2];  [2];  [2];  [3];  [3];  [4];  [5];  [2]
  1. Kingsport, TN
  2. Helsinki, FI
  3. Maple Grove, MN
  4. Cottage Grove, MN
  5. St. Bonifacius, MN
+ Show Author Affiliations

Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.

Research Organization:
Cargill Incorporated, Wayzata, MN, USA
Sponsoring Organization:
USDOE
DOE Contract Number:
FC07-021D14349
Assignee:
Cargill Incorporated (Wayzata, MN)
Patent Number(s):
8,623,633
Application Number:
13/107,882
OSTI ID:
1113979
Resource Relation:
Patent File Date: 2011 May 14
Country of Publication:
United States
Language:
English

References (13)

Xylose utilization by recombinant yeasts patent February 1999
Genetically engineered yeast and mutants thereof for the efficient fermentation of lignocellulose hydrolysates patent June 2002
Xylose isomerase with improved properties patent November 2002
Processes for preparing tertiary aminoalkylorganometallic compounds patent November 2002
Transformed eukaryotic cells that directly convert xylose to xylulose patent November 2009
Deletion of the GRE3 Aldose Reductase Gene and Its Influence on Xylose Metabolism in Recombinant Strains of Saccharomyces cerevisiae Expressing the xylA and XKS1 Genes journal December 2001
Yeast vectors for integration at the HO locus journal June 2001
High-level functional expression of a fungal xylose isomerase: the key to efficient ethanolic fermentation of xylose by ? journal October 2003
Minimal metabolic engineering of for efficient anaerobic xylose fermentation a proof of principle journal March 2004
Xylose isomerase activity influences xylose fermentation with recombinant Saccharomyces cerevisiae strains expressing mutated xylA from Thermus thermophilus journal April 2003
Xylulokinase Overexpression in Two Strains of Saccharomyces cerevisiae Also Expressing Xylose Reductase and Xylitol Dehydrogenase and Its Effect on Fermentation of Xylose and Lignocellulosic Hydrolysate journal September 2001
Amino Acid Substitutions in the Yeast Pichia Stipitis Xylitol Dehydrogenase Coenzyme-Binding Domain Affect the Coenzyme Specificity journal February 1995
Xylose metabolism in the anaerobic fungus Piromyces sp. strain E2 follows the bacterial pathway journal June 2003

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