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Title: Fatty acid-producing hosts

Described are hosts for overproducing a fatty acid product such as a fatty acid. The hosts include an exogenous nucleic acid encoding a thioesterase and, optionally, an exogenous nucleic acid encoding an acetyl-CoA carboxylase, wherein an acyl-CoA synthetase in the hosts are functionally delected. The hosts prefereably include the nucleic acid encoding the thioesterase at an intermediate copy number. The hosts are preferably recominantly stable and growth-competent at 37.degree. C. Methods of producing a fatty acid product comprising culturing such hosts at 37.degree. C. are also described.
Authors:
;
Publication Date:
OSTI Identifier:
1113235
Report Number(s):
8,617,856
12/984,343
DOE Contract Number:
FC02-07ER64494; FG02-03ER15468
Resource Type:
Patent
Research Org:
Wisconsin Alumni Research Foundation, Madison, WI, USA
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES