Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish
Abstract
Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar I (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP I individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population. 40 refs., 1 fig., 5 tabs.
- Authors:
-
- Yale Univ. School of Medicine, New Haven, CT (United States)
- National Institute of Mental Health, Bethesda, MD (United States)
- Univ. of Miami, FL (United States); and others
- Publication Date:
- OSTI Identifier:
- 110958
- Resource Type:
- Journal Article
- Journal Name:
- American Journal of Human Genetics
- Additional Journal Information:
- Journal Volume: 57; Journal Issue: 3; Other Information: PBD: Sep 1995
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; PATIENTS; HEREDITARY DISEASES; MENTAL DISORDERS; GENOTYPE; HUMAN CHROMOSOME 18; GENETIC MAPPING; ETIOLOGY; GENES; BIOLOGICAL MARKERS; STATISTICS; POLYMERASE CHAIN REACTION
Citation Formats
Pauls, D L, Paul, S M, Lilly Research Lab., Indianapolis, IN, and Allen, C R. Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish. United States: N. p., 1995.
Web.
Pauls, D L, Paul, S M, Lilly Research Lab., Indianapolis, IN, & Allen, C R. Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish. United States.
Pauls, D L, Paul, S M, Lilly Research Lab., Indianapolis, IN, and Allen, C R. 1995.
"Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish". United States.
@article{osti_110958,
title = {Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish},
author = {Pauls, D L and Paul, S M and Lilly Research Lab., Indianapolis, IN and Allen, C R},
abstractNote = {Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar I (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP I individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population. 40 refs., 1 fig., 5 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/110958},
journal = {American Journal of Human Genetics},
number = 3,
volume = 57,
place = {United States},
year = {Fri Sep 01 00:00:00 EDT 1995},
month = {Fri Sep 01 00:00:00 EDT 1995}
}
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