Rotanone analogs: method of preparation and use

VanBrocklin, Henry F; O'Neil, James P; Gibbs, Andrew R; Erathodiyil, Nandanan

Title: Rotanone analogs: method of preparation and use

Patent · Tue Oct 08 00:00:00 EDT 2013

OSTI ID:1097268

VanBrocklin, Henry F; O'Neil, James P; Gibbs, Andrew R; Erathodiyil, Nandanan

The present invention provides rotenone analogs and methods of making and using them. Labeled with single photon and positron emitting isotopes, the rotenone analogs of the present invention are useful in, for example, clinical imaging applications as tracers to measure cardiac blood flow and detect regions of ischemia.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC03-76F00098

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,551,448

Application Number:: 12/273,509

OSTI ID:: 1097268

Country of Publication:: United States

Language:: English

References (5)

Assay of [3H] Dihydrorotenone Binding to Complex I in Intact Human Platelets Blandini, F.; Greenamyre, J. T. Analytical Biochemistry, Vol. 230, Issue 1 https://doi.org/10.1006/abio.1995.1430	journal	September 1995
Synthesis of (2-[11C]methoxy)rotenone, a marker of mitochondrial complex I activity Charalambous, A.; Mangner, T. J.; Kilbourn, M. R. Nuclear Medicine and Biology, Vol. 22, Issue 1 https://doi.org/10.1016/0969-8051(94)00075-U	journal	January 1995
Biosynthesis of rotenone and amorphigenin. Study of the origins of isopropenyl-substituted dihydrofuran E-rings using isotopically labelled late precursors Bhandari, Prabha; Crombie, Leslie; Kilbee, Geoffrey W. Journal of the Chemical Society, Perkin Transactions 1, Issue 7 https://doi.org/10.1039/p19920000851	journal	January 1992
Technetium-99m hexakis 2-methoxy-2-isobutyl isonitrile and thallium-201 extraction, washout, and retention at varying coronary flow rates in rabbit heart. Marshall, R. C.; Leidholdt, E. M.; Zhang, D. Y. Circulation, Vol. 82, Issue 3 https://doi.org/10.1161/01.CIR.82.3.998	journal	September 1990
[F-18]-Fluororotenoids: Evaluation of Potential Myocardial Imaging Agents in an Isolated, Perfused Rabbit Heart Model OʼNeil, J. P.; Marshall, R. C.; Powers-Risius, P. Clinical Nuclear Medicine, Vol. 19, Issue 9 https://doi.org/10.1097/00003072-199409000-00051	journal	January 1994

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