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Title: Comparative Developmental Toxicity of Environmentally Relevant Oxygenated PAHs

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants in urban air, dust and in the soil of most industrial coal gassification, coal burning, coke production and wood preservation sites (Howsam and Jones 1998). It is widely recognized that PAHs pose risks to human health,having been associated with increased risks of systemic inflammation (Delfino et al. 2010), cardiopulmonary mortality (Lee et al. 2011; Lewtas 2007) and lung cancer mortality (Grant 2009; Hoshuyama et al. 2006). The potential risks may be especially acute for the developing fetus and infant where PAH exposures have been linked to low birth weight, intrauterine growth retardation, in-utero mortality and lower intelligence (Dejmek et al. 1999; Dejmek et al. 2000; Perera et al. 1999; Perera et al. 2009; Perera et al. 2006; Perera et al. 1998; Wu et al. 2010). Despite the more than two decades of intensive study devoted to parent PAHs, they are only part of the hazard spectrum from PAH contamination.
Authors:
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Publication Date:
OSTI Identifier:
1094916
Report Number(s):
PNNL-SA-91217
600306000
DOE Contract Number:
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicology and Applied Pharmacology, 271(2):266-275
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English