Effects of Methylphenidate on Resting-State Functional Connectivity of the Mesocorticolimbic Dopamine Pathways in Cocaine Addiction
Journal Article
·
· JAMA Psychiatry
Cocaine addiction is associated with altered resting-state functional connectivity among regions of the mesocorticolimbic dopamine pathways. Methylphenidate hydrochloride, an indirect dopamine agonist, normalizes task-related regional brain activity and associated behavior in cocaine users; however, the neural systems–level effects of methylphenidate in this population have not yet been described. To use resting-state functional magnetic resonance imaging to examine changes in mesocorticolimbic connectivity with methylphenidate and how connectivity of affected pathways relates to severity of cocaine addiction.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 1093197
- Report Number(s):
- BNL-101229-2013-JA; R&D Project: MO-085; KP1602010
- Journal Information:
- JAMA Psychiatry, Vol. 70, Issue 8; ISSN 2168-622X
- Country of Publication:
- United States
- Language:
- English
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