Surface sampling concentration and reaction probe

Van Berkel, Gary J; Elnaggar, Mariam S

Title: Surface sampling concentration and reaction probe

Patent · Tue Jul 16 00:00:00 EDT 2013

OSTI ID:1087878

Van Berkel, Gary J; Elnaggar, Mariam S

A method of analyzing a chemical composition of a specimen is described. The method can include providing a probe comprising an outer capillary tube and an inner capillary tube disposed co-axially within the outer capillary tube, where the inner and outer capillary tubes define a solvent capillary and a sampling capillary in fluid communication with one another at a distal end of the probe; contacting a target site on a surface of a specimen with a solvent in fluid communication with the probe; maintaining a plug volume proximate a solvent-specimen interface, wherein the plug volume is in fluid communication with the probe; draining plug sampling fluid from the plug volume through the sampling capillary; and analyzing a chemical composition of the plug sampling fluid with an analytical instrument. A system for performing the method is also described.

View Patent

Cite

Export

Save

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: 8,486,703

Application Number:: 12/894,872

OSTI ID:: 1087878

Country of Publication:: United States

Language:: English

References (58)

Disposable Containers and Utensils for Sanitizing Kendall, Yvette Kathrynn https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090263440 US Patent Application 12/427129; 20090263440	patent-application	October 2009
Hollow nanoparticle generation on laser-induced cavitation bubbles via bubble interface pinning Yan, Zijie; Bao, Ruqiang; Wright, Roger N. Applied Physics Letters, Vol. 97, Issue 12 https://doi.org/10.1063/1.3488003	journal	September 2010
Laser ablation in liquids: Applications in the synthesis of nanocrystals Yang, G. Progress in Materials Science, Vol. 52, Issue 4 https://doi.org/10.1016/j.pmatsci.2006.10.016	journal	May 2007
Direct flow injection analysis nebulization electrospray and APCI mass spectrometry Andrien, JR., Bruce A.; Banks, J. Fred; Boyle, James https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20020168778 US Patent Application 10/150692; 20020168778	patent-application	November 2002
Disposable combination cup and base Zimmer, John https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4865199 US Patent Document 4,865,199	patent	September 1989
Laser desorption—electrospray ion (ESI) source for mass spectrometers Kovtoun, Viatcheslav V. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7525105 US Patent Document 7,525,105	patent	April 2009
Automated Analysis Of Complex Matrices Using Mass Spectrometer Keiser, Byron https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070138384 US Patent Application 11/567281; 20070138384	patent-application	June 2007
Method and apparatus for continuous sample deposition on sample support plates for liquid chromatography-matrix-assisted laser desorption/ionization mass spectrometry Stacey, Catherine https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040023410 US Patent Application 10/213144; 20040023410	patent-application	February 2004
Methods and compositions for assessing a sample by maldi mass spectrometry Lopes-Avila, Viorica; Hirschberg, David L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050178959 US Patent Application 11/001493; 20050178959	patent-application	August 2005
Transmission studies of explosive vaporization of a transparent liquid film on an opaque solid surface induced by excimer‐laser‐pulsed irradiation Leung, P. T.; Do, Nhan; Klees, Leander Journal of Applied Physics, Vol. 72, Issue 6 https://doi.org/10.1063/1.351619	journal	September 1992
Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples Everett, Nicholas P.; Petell, James K.; Young, Scott A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7445907 US Patent Document 7,445,907	patent	November 2008
Apparatus and method for isolating a nucleic acid from a sample Bortolin, Laura T.; Parameswaran, Lalitha; Bobrow, JOhanna https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080131949 US Patent Application 11/804598; 20080131949	patent-application	June 2008
Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) Hafeman, Dean; Dill, Kilian; Harkins, James B. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050116161 US Patent Application 10/963336; 20050116161	patent-application	June 2005
Method for selective removal of a material from a wafer's alignment marks Sandhu, Gurtej S.; Laulusa, Alan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5271798 US Patent Document 5,271,798	patent	December 1993
Pulsed laser‐induced desorption and optical imaging on a nanometer scale with scanning near‐field microscopy using chemically etched fiber tips Zeisel, Dieter; Nettesheim, Stefan; Dutoit, Bertrand Applied Physics Letters, Vol. 68, Issue 18 https://doi.org/10.1063/1.115831	journal	April 1996
Evidence of near-field laser ablation inductively coupled plasma mass spectrometry (NF-LA-ICP-MS) at nanometre scale for elemental and isotopic analysis on gels and biological samples Becker, J. Sabine; Gorbunoff, André; Zoriy, Miroslav J. Anal. At. Spectrom., Vol. 21, Issue 1 https://doi.org/10.1039/B514401A	journal	January 2006
Differential Hemolysis of a Whole Blood Sample Kobold, Uwe; Duelffer, Thomas; Herrmann, Rupert https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090253210 US Patent Application 12/328890; 20090253210	patent-application	October 2009
Mass Spectrometry With Laser Ablation Nikolaev, Evgenij; Franzen, Jochen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080128614 US Patent Application 11/943904; 20080128614	patent-application	June 2008
Composite analyzer tester Collins, Richard M.; Chance, Richard F. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4745809 US Patent Document 4,745,809	patent	May 1988
Towards Nanoscale Molecular Analysis at Atmospheric Pressure by a Near-Field Laser Ablation Ion Trap/Time-of-Flight Mass Spectrometer Schmitz, Thomas A.; Gamez, Gerardo; Setz, Patrick D. Analytical Chemistry, Vol. 80, Issue 17 https://doi.org/10.1021/ac8005044	journal	September 2008
Sampling probe for microarray read out using electrospray mass spectrometry Van Berkel, Gary J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6803566 US Patent Document 6,803,566	patent	October 2004
Recyclable corrugated beverage container and holder Coffin, Sr., David W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5205473 US Patent Document 5,205,473	patent	April 1993
Optical reflectance and scattering studies of nucleation and growth of bubbles at a liquid-solid interface induced by pulsed laser heating Yavas, Oguz; Leiderer, Paul; Park, Hee K. Physical Review Letters, Vol. 70, Issue 12 https://doi.org/10.1103/PhysRevLett.70.1830	journal	March 1993
Possibility of nano-local element analysis by near-field laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS): New experimental arrangement and first application Zoriy, Myroslav V.; Kayser, Markus; Becker, J. Sabine International Journal of Mass Spectrometry, Vol. 273, Issue 3, p. 151-155 https://doi.org/10.1016/j.ijms.2008.03.008	journal	June 2008
Electrospray-Assisted Laser-Induced Acoustic Desorption Ionization Mass Spectrometer and a Method for Mass Spectrometry Shiea, Jentaie https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080308722 US Patent Application 12/112532; 20080308722	patent-application	December 2008
Beverage Pod Delorme, Kevin S. J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110259205 US Patent Application 12/767478; 20110259205	patent-application	October 2011
Quantitative Analysis of Surface-Derived Samples using Mass Spectrometry Cerda, Blas https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070259445 US Patent Application 11/744513; 20070259445	patent-application	November 2007
Disposable beverage container Mitri, George https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4726487 US Patent Document 4,726,487	patent	February 1988
Laser desorption - electrospray ion (ESI) source for mass spectrometers Kovtoun, Viatcheslav V. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080272294 US Patent Document 11/799910; 20080272294	patent-application	November 2008
Method of Preparing Sample for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Sato, Taka-aki; Aoki, Yutaka; Shimada, Takashi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100038529 US Patent Application 12/443461; 20100038529	patent-application	February 2010
Method and system for formation and withdrawal of a sample from a surface to be analyzed Van Berkel, Gary J.; Kertesz, Vilmos https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100224013 US Patent Application 12/380980; 20100224013	patent-application	September 2010
Increasing Ionization Efficiency in Mass Spectroscopy Schneider, Luke V. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090121124 US Patent Application 12/167140; 20090121124	patent-application	May 2009
Field enhancement in apertureless near-field scanning optical microscopy Bohn, John L.; Nesbitt, D. J.; Gallagher, A. Journal of the Optical Society of America A, Vol. 18, Issue 12 https://doi.org/10.1364/JOSAA.18.002998	journal	January 2001
Near-Field Scanning Optical Microscopy Dunn, Robert C. Chemical Reviews, Vol. 99, Issue 10 https://doi.org/10.1021/cr980130e	journal	October 1999
Laser ablation in liquids as a new technique of sampling in elemental analysis of solid materials Muravitskaya, E. V.; Rosantsev, V. A.; Belkov, M. V. Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 64, Issue 2, p. 119-125 https://doi.org/10.1016/j.sab.2008.11.003	journal	February 2009
Device for Processing a Biological And/or Chemical Sample and Method of Using the Same Oviso, Jr., Dominador Fortaleza; Ting, Dor Ngi; Ghadessy, Farid https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090053689 US Patent Application 11/996,237; 2009/0053689 Al	patent-application	February 2009
Miniaturized fluid transfer device Wachs, Timothy; Henion, Jack https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6478238 US Patent Document 6,478,238	patent	November 2002
High power laser induced acoustic desorption probe Shea, Ryan C.; Kenttamaa, Hikka I.; Vaughn, Weldon E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070295902 US Patent Application 11/807400; 20070295902	patent-application	December 2007
System and method for on-line coupling of liquid capillary separations with matrix-assisted laser desorption/ionization mass spectrometry Gusev, Arkady I.; Hercules, David M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6140639 US Patent Document 6,140,639	patent	October 2000
Ion Generation Using Wetted Porous Material Ouyang, Zheng; Wang, He; Manicke, Nicholas E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120119079 US Patent Document 13/265110; 20120119079	patent-application	May 2012
Protein crystallization in microfluidic structures Weigl, Bernhard; Sygusch, Jurgen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6409832 US Patent Document 6,409,832	patent	June 2002
Detection of malaria parasites by mass spectrometry Demirev, Plamen A.; Feldman, Andrew B.; Kongkasuriyachai, Darin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7270948 US Patent Document 7,270,948	patent	September 2007
Means and method for analyzing samples by mass spectrometry Park, Melvin A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070224697 US Patent Application 11/388745; 20070224697	patent-application	September 2007
Near-Field Optical Microscopy and Spectroscopy with Pointed Probes Novotny, Lukas; Stranick, Stephan J. Annual Review of Physical Chemistry, Vol. 57, Issue 1 https://doi.org/10.1146/annurev.physchem.56.092503.141236	journal	May 2006
Method and apparatus for etch of a specific subarea of a semiconductor work object Morgan, Paul A.; Torek, Kevin J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6290863 US Patent Document 6,290,863	patent	September 2001
Microsecond-resolved imaging of laser ablation at solid–liquid interface: investigation of formation process of nano-size metal colloids Tsuji, Takeshi; Tsuboi, Yasuyuki; Kitamura, Noboru Applied Surface Science, Vol. 229, Issue 1-4, p. 365-371 https://doi.org/10.1016/j.apsusc.2004.02.013	journal	May 2004
Method and apparatus for the quantitative measurement of the corrosivity effect of residues present on the surface of electronic circuit assemblies Munson, Terry L.; Pauls, Douglas O. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5783938 US Patent Document 5,783,938	patent	July 1998
Mass spectroscopic reaction-monitoring method Shiea, Jentaie; Yuan, Cheng-Hui; Jheng, Jhih-Yuan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7718958 US Patent Document 7,718,958	patent	May 2010
Looking at the nanoscale: scanning near-field optical microscopy De Serio, M. TrAC Trends in Analytical Chemistry, Vol. 22, Issue 2 https://doi.org/10.1016/S0165-9936(03)00201-2	journal	February 2003
Bubble nucleation and pressure generation during laser cleaning of surfaces Yavas, O.; Schilling, A.; Bischof, J. Applied Physics A: Materials Science & Processing, Vol. 64, Issue 4 https://doi.org/10.1007/s003390050487	journal	April 1997
Container and method of making a container Kosth, Daniel A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050276937 US Patent Application 11/152481; 20050276937	patent-application	December 2005
Multi-function laser induced breakdown spectroscopy and laser ablation material analysis system and method Roy, John W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070046934 US Patent Document 11/213057; 20070046934	patent-application	March 2007
Methods for Molecular Nanoanalysis Schmid, Thomas; Schmitz, Thomas A.; Setz, Patrick D. CHIMIA International Journal for Chemistry, Vol. 60, Issue 11 https://doi.org/10.2533/chimia.2006.783	journal	November 2006
Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry Stöckle, Raoul; Setz, Patrick; Deckert, Volker Analytical Chemistry, Vol. 73, Issue 7 https://doi.org/10.1021/ac001440b	journal	April 2001
Interface members and holders for microfluidic array devices Staats, Sau Lan Tang https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6864480 US Patent Document 6,864,480	patent	March 2005
Sampling probe for microarray read out using electrospray mass spectrometry Van Berkel, Gary https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030193020 US Patent Application 10/123629; 20030193020	patent-application	October 2003
Methods and apparatus for ink delivery to nanolithographic probe systems Cruchon-Dupeyrat, Sylvain; Nelson, Michael; Elghanian, Robert https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7762638 US Patent Document 7,762,638	patent	July 2010
The irradiation effect of a Nd–YAG pulsed laser on the CeO₂ target in the liquid Chen, Jiwei; Dong, Qizhi; Yang, Jing Materials Letters, Vol. 58, Issue 3-4, p. 337-341 https://doi.org/10.1016/S0167-577X(03)00482-8	journal	January 2004

Similar Records

Surface sampling concentration and reaction probe with controller to adjust sampling position

Patent · Tue Jul 19 00:00:00 EDT 2016 · OSTI ID:1087878

Van Berkel, Gary J.; ElNaggar, Mariam S.

Liquid Microjunction Surface Sampling Probe Fluid Dynamics: Computational and Experimental Analysis of Coaxial Intercapillary Positioning Effects on Sample Manipulation

Journal Article · Sat Jan 01 00:00:00 EST 2011 · Journal of the American Society for Mass Spectrometry · OSTI ID:1087878

ElNaggar, Mariam S; Barbier, Charlotte N; Van Berkel, Gary J

Sampling probe for stack gas monitoring system

Patent · Tue Apr 12 00:00:00 EST 1983 · OSTI ID:1087878

Wood, R D

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Title: Surface sampling concentration and reaction probe

Citation Formats

References (58)

Similar Records

Related Subjects