A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination
Abstract
We have used a half-YAC containing the human chromosome 21 long-arm telomere to clone, map, and characterize a new dinucleotide repeat polymorphism (D21S1575) close to 21qter. The marker is <120 kb from the telomeric (TTAGGG){sub n} sequences and is the most distal highly polymorphic marker on chromosome 21q. This marker has a heterozygosity of 71% because of a variable (TA){sub n} repeat embedded within a long interspersed element (LINE) element. Genotyping of the CEPH families and linkage analysis provided a more accurate determination of the full length of the chromosome 21 genetic map. A highly significant difference was detected between male and female recombination rates in the telomeric region: in the most telomeric 2.3 Mb of chromosome 21q, recombination was only observed in male meioses. 35 refs., 4 figs., 2 tabs.
- Authors:
-
- Cantonal Hospital of Geneva (Switzerland); and others
- Publication Date:
- OSTI Identifier:
- 105247
- Resource Type:
- Journal Article
- Journal Name:
- American Journal of Human Genetics
- Additional Journal Information:
- Journal Volume: 57; Journal Issue: 2; Other Information: PBD: Aug 1995
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; GENES; GENE MUTATIONS; GENE RECOMBINATION; SEX DEPENDENCE; TELOMERES; GENETIC MAPPING; HUMAN CHROMOSOME 21; CHROMOSOMAL ABERRATIONS; BIOLOGICAL MARKERS; RESOLUTION; ANIMAL CELLS; MEIOSIS; NUCLEOTIDES; YEASTS; DNA-CLONING; GENOTYPE
Citation Formats
Blouin, J L, Gos, A, and Morris, M A. A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination. United States: N. p., 1995.
Web.
Blouin, J L, Gos, A, & Morris, M A. A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination. United States.
Blouin, J L, Gos, A, and Morris, M A. 1995.
"A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination". United States.
@article{osti_105247,
title = {A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination},
author = {Blouin, J L and Gos, A and Morris, M A},
abstractNote = {We have used a half-YAC containing the human chromosome 21 long-arm telomere to clone, map, and characterize a new dinucleotide repeat polymorphism (D21S1575) close to 21qter. The marker is <120 kb from the telomeric (TTAGGG){sub n} sequences and is the most distal highly polymorphic marker on chromosome 21q. This marker has a heterozygosity of 71% because of a variable (TA){sub n} repeat embedded within a long interspersed element (LINE) element. Genotyping of the CEPH families and linkage analysis provided a more accurate determination of the full length of the chromosome 21 genetic map. A highly significant difference was detected between male and female recombination rates in the telomeric region: in the most telomeric 2.3 Mb of chromosome 21q, recombination was only observed in male meioses. 35 refs., 4 figs., 2 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/105247},
journal = {American Journal of Human Genetics},
number = 2,
volume = 57,
place = {United States},
year = {Tue Aug 01 00:00:00 EDT 1995},
month = {Tue Aug 01 00:00:00 EDT 1995}
}