Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

Journal Article · Sun Jul 01 00:00:00 EDT 2012 · Anticancer Research

OSTI ID:1049381

Molinari, Ana J; Aromando, Romina F; Itoiz, Maria E; Garabalino, Marcela A; Hughes, Andrea Monti; Heber, Elisa M; Pozzi, Emiliano C. C.; Nigg, David W; Trivillin, Veronica A; Schwint, Amanda E

Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

• Research Organization: Idaho National Lab. (INL), Idaho Falls, ID (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: DE-AC07-05ID14517
• OSTI ID: 1049381
• Report Number(s): INL/JOU-12-26991; ANTRD4; TRN: US201218%%1446
• Journal Information: Anticancer Research, Vol. 32, Issue 7; ISSN 0250-7005
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
BLOOD
BLOOD VESSELS
DELIVERY
DRUGS
DYES
EVANS BLUE
HAMSTERS
HEAD
IN VIVO
MORPHOLOGY
NECK
NEOPLASMS
ORAL CAVITY
OXYGEN
REDUCTION
THERAPY
blood vessel normalization
hamster cheek pouch oral cancer model
oral cancer
thalidomide