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Title: Main chain acid-degradable polymers for the delivery of bioactive materials

Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.
Authors:
 [1] ;  [2] ;  [3] ;  [4]
  1. Oakland, CA
  2. Evanston, IL
  3. Milpitas, CA
  4. Cambridge, MA
Publication Date:
OSTI Identifier:
1039708
Report Number(s):
8,137,700
US patent application 12/299,506
DOE Contract Number:
AC02-05CH11231
Resource Type:
Patent
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE