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Title: Dihydro-resveratrol-A potent dietary polyphenol

Abstract

Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and -562).

Authors:
 [1];  [2];  [2];  [3];  [4];  [4];  [4];  [4];  [4]
  1. ORNL
  2. N.N. Blokhin Russian Cancer Research Center
  3. Hefei National Laboratory for the Physical Sciences at Microscale
  4. Chemical Diversity Research Institute
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1038463
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Journal Name:
Bioorganic and Medicinal Chemistry Letters
Additional Journal Information:
Journal Volume: 20; Journal Issue: 20; Journal ID: ISSN 0960-894X
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; HORMONES; MAMMARY GLANDS; NEOPLASMS; POLYPHENOLS; TUMOR CELLS; Resveratrol; cancer; estrogen receptors

Citation Formats

Gakh, Andrei A, Anisimova, Natalia Yu, Kiselevsky, Mikhail V, Sadovnikov, Sergey V, Stankov, Ivan N, Yudin, Mikhail V, Rufanov, Konstantin A, Krasavin, Mikhail Yu, and Sosnov, Andrey V. Dihydro-resveratrol-A potent dietary polyphenol. United States: N. p., 2010. Web. doi:10.1016/j.bmcl.2010.08.002.
Gakh, Andrei A, Anisimova, Natalia Yu, Kiselevsky, Mikhail V, Sadovnikov, Sergey V, Stankov, Ivan N, Yudin, Mikhail V, Rufanov, Konstantin A, Krasavin, Mikhail Yu, & Sosnov, Andrey V. Dihydro-resveratrol-A potent dietary polyphenol. United States. https://doi.org/10.1016/j.bmcl.2010.08.002
Gakh, Andrei A, Anisimova, Natalia Yu, Kiselevsky, Mikhail V, Sadovnikov, Sergey V, Stankov, Ivan N, Yudin, Mikhail V, Rufanov, Konstantin A, Krasavin, Mikhail Yu, and Sosnov, Andrey V. 2010. "Dihydro-resveratrol-A potent dietary polyphenol". United States. https://doi.org/10.1016/j.bmcl.2010.08.002.
@article{osti_1038463,
title = {Dihydro-resveratrol-A potent dietary polyphenol},
author = {Gakh, Andrei A and Anisimova, Natalia Yu and Kiselevsky, Mikhail V and Sadovnikov, Sergey V and Stankov, Ivan N and Yudin, Mikhail V and Rufanov, Konstantin A and Krasavin, Mikhail Yu and Sosnov, Andrey V},
abstractNote = {Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and -562).},
doi = {10.1016/j.bmcl.2010.08.002},
url = {https://www.osti.gov/biblio/1038463}, journal = {Bioorganic and Medicinal Chemistry Letters},
issn = {0960-894X},
number = 20,
volume = 20,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 2010},
month = {Fri Jan 01 00:00:00 EST 2010}
}