Global radiation damage at 300 and 260 K with dose rates approaching 1 MGy s[superscript -1]

Journal Article · Mon Feb 27 00:00:00 EST 2012 · Acta Crystallographica Section D: Biological Crystallography

DOI:https://doi.org/10.1107/S0907444911052085· OSTI ID:1035707

Warkentin, Matthew; Badeau, Ryan; Hopkins, Jesse B; Mulichak, Anne M; Keefe, Lisa J; Thorne, Robert E ^[1]

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1. Cornell

Global radiation damage to 19 thaumatin crystals has been measured using dose rates from 3 to 680 kGy s{sup -1}. At room temperature damage per unit dose appears to be roughly independent of dose rate, suggesting that the timescales for important damage processes are less than {approx}1 s. However, at T = 260 K approximately half of the global damage manifested at dose rates of {approx}10 kGy s{sup -1} can be outrun by collecting data at 680 kGy s{sup -1}. Appreciable sample-to-sample variability in global radiation sensitivity at fixed dose rate is observed. This variability cannot be accounted for by errors in dose calculation, crystal slippage or the size of the data sets in the assay.

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: NSFNIH
• OSTI ID: 1035707
• Journal Information: Acta Crystallographica Section D: Biological Crystallography, Vol. 68, Issue 2; ISSN 0907-4449
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
CRYSTALLOGRAPHY
DOSE RATES
PROTEINS
RADIATIONS
SENSITIVITY