Drug release from hydrazone-containing peptide amphiphiles
- NWU
Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine E-amine allowed for precise placement of a hydrazide in a peptide sequence.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- OTHER
- OSTI ID:
- 1034185
- Journal Information:
- Chem. Commun., Vol. 47, Issue (28) ; 2011
- Country of Publication:
- United States
- Language:
- ENGLISH
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