Unique Gene-Silencing and Structural Properties of 2;#8242;-Fluoro-Modified siRNAs
Journal Article
·
· Angewandte Chemie (International Edition)
- Binghamton
With little or no negative impact on the activity of small interfering RNAs (siRNAs), regardless of the number of modifications or the positions within the strand, the 2'-deoxy-2'-fluoro (2'-F) modification is unique. Furthermore, the 2'-F-modified siRNA (see crystal structure) was thermodynamically more stable and more nuclease-resistant than the parent siRNA, and produced no immunostimulatory response.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- National Institutes of Health (NIH)
- OSTI ID:
- 1031926
- Journal Information:
- Angewandte Chemie (International Edition), Vol. 50, Issue (10) ; 03, 2011; ISSN 1433-7851
- Country of Publication:
- United States
- Language:
- ENGLISH
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