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Title: COMPACT CdZnTe-BASED GAMMA CAMERA FOR PROSTATE CANCER IMAGING

In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high false-positive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, amore » few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integrated-circuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera have been completed. The results show better than 6-mm resolution at a distance of 1 cm. Details of the test results are discussed in this paper.« less
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Publication Date:
OSTI Identifier:
1029248
Report Number(s):
BNL--96182-2011-CP
R&D Project: 87092; 87092; 650201010and600301020; TRN: US1105706
DOE Contract Number:
DE-AC02-98CH10886
Resource Type:
Conference
Resource Relation:
Conference: 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference (2011 NSS/MIC); Valencia, Spain; 20111023 through 20111029
Research Org:
Brookhaven National Laboratory (BNL) Positron Emission Tomography (PET) Facility
Sponsoring Org:
DOE - OFFICE OF SOLAR TECHNOLOGIES
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 36 MATERIALS SCIENCE; BIOPSY; CADMIUM TELLURIDES; CAMERAS; COMPTON EFFECT; DETECTION; DIAGNOSIS; DISEASES; ELECTRON MOBILITY; ENERGY RESOLUTION; GAMMA CAMERAS; NEOPLASMS; MEN; ORGANS; PROSTATE; RADIATION DETECTORS; SEMICONDUCTOR MATERIALS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SPATIAL RESOLUTION; ZINC TELLURIDES CdZnTe; RADIATION DETECTORS; PROSTATE CANCER; NUCLEAR MEDICAL IMAGING; GAMMA CAMERA; positron emission tomography (PET) facility