Structures of Triacetyloleandomycin and Mycalamide A Bound to the Large Ribosomal Subunit of Haloarcula marismortui
Journal Article
·
· Antimicrobial Agents and Chemotherapy
Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
- Sponsoring Organization:
- DOE - OFFICE OF SCIENCE
- DOE Contract Number:
- DE-AC02-98CH10886
- OSTI ID:
- 1020153
- Report Number(s):
- BNL-96003-2011-JA; AMACCQ; TRN: US201116%%133
- Journal Information:
- Antimicrobial Agents and Chemotherapy, Vol. 53, Issue 12; ISSN 0066-4804
- Country of Publication:
- United States
- Language:
- English
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