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Title: In vivo chelation of Am(III), Pu(IV), Np(V), and U(VI) in mice by TREN-(Me-3,2-HOPO)

Octadentate 3,4,3-LI(1,2-HOPO), composed of the acidic hydroxypyridine isomer, 1,2-HOPO, is the most effective ligand yet prepared for in vivo chelation of Pu(IV) and Am(III), but it is difficult to prepare and acutely toxic. Hexadentate TREN-(Me-3,2-HOPO), composed of the less acidic Me-3,2-HOPO isomer, can be produced in relatively large quantities. TREN-(Me-3,2-HOPO) (30 {mu}mol.kg{sup {minus}1} injected intraperitoneally in mice 3 min to 1 h after intravenous injection of an actinide) removed significant body Pu(IV), Am(III), Np(V), or U(VI) (compared with controls), and those actinide reductions were significantly greater than were obtained with CaNa{sub 3}-DTPA. TREN-(Me-3,2-HOPO) was almost as effective for reducing body PU(IV) as 3,4,3-LI(1,2-HOPO). TREN-(Me-3,2-HOPO) is of low acute toxicity in mice and its clinical potential, as a practical compromise between the effectiveness of 3,4,3-LI(1,2-HOPO) and the safety of CaNa{sub 3}-DTPA, merits further investigation.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
10190182
Report Number(s):
LBL--34569; CONF-9309138--1
ON: DE94000569; CNN: Grant ES02698
DOE Contract Number:
AC03-76SF00098
Resource Type:
Conference
Resource Relation:
Conference: Intakes of radionuclide detection, assessment and limitation of occupational exposure,Bath (United Kingdom),13-17 Sep 1993; Other Information: PBD: Aug 1993
Research Org:
Lawrence Berkeley Lab., CA (United States)
Sponsoring Org:
USDOE, Washington, DC (United States);Department of Health and Human Services, Washington, DC (United States);Department of Defense, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AMERICIUM; TISSUE DISTRIBUTION; PLUTONIUM; NEPTUNIUM; URANIUM; RADIOPROTECTIVE SUBSTANCES; COMPARATIVE EVALUATIONS; MICE; CHELATES; SKELETON; LIVER; KIDNEYS; FECES 560162; ANIMALS, PLANTS, MICROORGANISMS, AND CELLS