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Title: Salmonella-secreted Virulence Factors

In this short review we discuss secreted virulence factors of Salmonella, which directly affect Salmonella interaction with its host. Salmonella secretes protein to subvert host defenses but also, as discussed, to reduce virulence thereby permitting the bacteria to persist longer and more successfully disperse. The type III secretion system (TTSS) is the best known and well studied of the mechanisms that enable secretion from the bacterial cytoplasm to the host cell cytoplasm. Other secretion systems include outer membrane vesicles, which are present in all Gram-negative bacteria examined to date, two-partner secretion, and type VI secretion will also be addressed. Excellent reviews of Salmonella secreted effectors have focused on themes such as actin rearrangements, vesicular trafficking, ubiquitination, and the activities of the virulence factors themselves. This short review is based on S. Typhimurium infection of mice because it is a model of typhoid like disease in humans. We have organized effectors in terms of events that happen during the infection cycle and how secreted effectors may be involved.
Authors:
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Publication Date:
OSTI Identifier:
1015521
Report Number(s):
PNNL-SA-71401
400412000; TRN: US201111%%641
DOE Contract Number:
AC05-76RL01830
Resource Type:
Book
Resource Relation:
Related Information: Salmonella: From Genome to Function, 187-223
Publisher:
S Porwollik; Caister Academic Press, Norfolk, United Kingdom.
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; ACTIN; BACTERIA; CYTOPLASM; DISEASES; MEMBRANES; MICE; PROTEINS; SALMONELLA; SECRETION; TYPHOID; VIRULENCE ENTERICA SEROVAR TYPHIMURIUM; T-CELL RESPONSES; LYSOSOMAL; MEMBRANE-GLYCOPROTEINS; PHOSPHOTHREONINE LYASE ACTIVITY; LATE ENDOCYTIC COMPARTMENTS; NUCLEOTIDE EXCHANGE FACTOR; ACTIN-BINDING PROTEINS; B-ALPHA UBIQUITINATION; III EFFECTOR FAMILY; NF-KAPPA-B