Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Thanos, P K

Title: Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

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Abstract

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R{sup +/+}), both heterozygous (D4R{sup +/-}) and knockout (D4R{sup -/-}) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

Authors:: Thanos, P K

Publication Date:: Thu Oct 22 00:00:00 EDT 2009

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: DOE - OFFICE OF SCIENCE

OSTI Identifier:: 1014288

Report Number(s):: BNL-91369-2010-JA
R&D Project: MO085; KP1602010; TRN: US201111%%241

DOE Contract Number:: DE-AC02-98CH10886

Resource Type:: Journal Article

Journal Name:: Behavioural Brain Research

Additional Journal Information:: Journal Volume: 207; Journal Issue: 2

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; COCAINE; DOPAMINE; FOOD; GENETICS; MICE; PELLETS; reward; addiction; reinforcement; cognition; dopamine; receptors; mice; food; cocaine

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                    Thanos, P K. Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine.  United States: N. p., 2009. 
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                    Thanos, P K. Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine.  United States.

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                    Thanos, P K. 2009.  
        "Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine".  United States.

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@article{osti_1014288,

  title        = {Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine},

  author       = {Thanos, P K},

  abstractNote = {In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R{sup +/+}), both heterozygous (D4R{sup +/-}) and knockout (D4R{sup -/-}) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/1014288},
  journal      = {Behavioural Brain Research},
number       = 2,

  volume       = 207,

  place        = {United States},

  year         = {Thu Oct 22 00:00:00 EDT 2009},

  month        = {Thu Oct 22 00:00:00 EDT 2009}

}

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Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Journal Article Thanos, P - Behavioural Brain Research

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/−) and knockout (D4R−/−) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.
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