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Title: Smarter Drugs: How Protein Crystallography Revolutionizes Drug Design

According to Smith, protein crystallography allows scientists to design drugs in a much more efficient way than the standard methods traditionally used by large drug companies, which can cost close to a billion dollars and take 10 to 15 years. 'A lot of the work can be compressed down,' Smith said. Protein crystallography enables researchers to learn the structure of molecules involved in disease and health. Seeing the loops, folds and placement of atoms in anything from a virus to a healthy cell membrane gives important information about how these things work - and how to encourage, sidestep or stop their functions. Drug design can be much faster when the relationship between structure and function tells you what area of a molecule to target. Smith will use a timeline to illustrate the traditional methods of drug development and the new ways it can be done now. 'It is very exciting work. There have been some failures, but many successes too.' A new drug to combat the flu was developed in a year or so. Smith will tell us how. He will also highlight drugs developed to combat HIV, Tuberculosis, hypertension and Anthrax.
Authors:
Publication Date:
OSTI Identifier:
1014029
DOE Contract Number:
AC02-76SF00515
Resource Type:
Conference
Resource Relation:
Conference: SLAC Public Lecture Series, SLAC National Accelerator Laboratory, Menlo Park, California, presented on April 26, 2005
Research Org:
SLAC (SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States))
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; AIDS VIRUS; ATOMS; CELL MEMBRANES; CRYSTALLOGRAPHY; DESIGN; DISEASES; DOLLARS; FERMILAB ACCELERATOR; HYPERTENSION; PROTEINS; STANFORD LINEAR ACCELERATOR CENTER; TUBERCULOSIS