skip to main content

Title: Gastrointestinal absorption of plutonium, uranium and neptunium in fed and fasted adult baboons: Application to humans

Gastrointestinal (GI) absorption values of plutonium, uranium, and neptunium were determined in fed and fasted adult baboons. A dual isotope method of determining GI absorption, which does not require animal sacrifice, was validated and shown to compare well with the sacrifice method (summation of oral isotope in urine with that in tissues at sacrifice). For all three elements, mean GI absorption values were significantly high (5- to 50-fold) in 24-hour (h)-fasted animals than in fed animals, and GI absorption values for baboons agreed well with those for humans.
Authors:
; ; ;  [1] ; ; ;  [2]
  1. Argonne National Lab., IL (United States)
  2. New York Univ. Medical Center, Tuxedo, NY (United States)
Publication Date:
OSTI Identifier:
10135067
Report Number(s):
NUREG/CR--5842; ANL--92/8
ON: TI92010486
DOE Contract Number:
W-31109-ENG-38
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: Mar 1992
Research Org:
Nuclear Regulatory Commission, Washington, DC (United States). Div. of Regulatory Applications; Argonne National Lab., IL (United States)
Sponsoring Org:
Nuclear Regulatory Commission, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; URANIUM; INTESTINAL ABSORPTION; NEPTUNIUM; PLUTONIUM; PLUTONIUM 236; TISSUE DISTRIBUTION; PLUTONIUM 238; NEPTUNIUM 239; NEPTUNIUM 237; URANIUM 233; URANIUM 236; BABOONS; INGESTION; GASTROINTESTINAL TRACT; METABOLISM; SKELETON; COMPARATIVE EVALUATIONS; HUMAN POPULATIONS 560162; 560161; ANIMALS, PLANTS, MICROORGANISMS, AND CELLS; MAN