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Title: Closure for milliliter scale bioreactor

A closure for a microreactor includes a cap that is configured to be inserted into a well of the microreactor. The cap, or at least a portion of the cap, is compliant so as to form a seal with the well when the cap is inserted. The cap includes an aperture that provides an airway between the inside of the well to the external environment when the cap is inserted into the well. A porous plug is inserted in the aperture, e.g., either directly or in tube that extends through the aperture. The porous plug permits gas within the well to pass through the aperture while preventing liquids from passing through to reduce evaporation and preventing microbes from passing through to provide a sterile environment. A one-way valve may also be used to help control the environment in the well.
Authors:
 [1] ;  [2] ;  [1] ;  [3]
  1. (Palo Alto, CA)
  2. (Albany, CA)
  3. (Moss Beach, CA)
Publication Date:
OSTI Identifier:
1010278
Report Number(s):
7,851,204
US patent application 11/450,855
DOE Contract Number:
FG02-04ER83963
Resource Type:
Patent
Research Org:
Gener 8 Inc
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English