Why does TNA cross-pair more strongly with RNA than with DNA? An answer from X-ray analysis
Journal Article
·
· Angew. Chem. Int. Ed.
OSTI ID:1008784
- Vanderbilt
L-{alpha}-threofuranosyl (3' {yields} 2') nucleic acid (TNA) residues adopt a C4'-exo pucker when incorporated into an A- (left) or a B-form DNA duplex (right). The resulting intranucleotide P {hor_ellipsis} P distance in TNA is very similar to that in RNA (represented by a C3'-endo puckered adenosine residue; green). The structural data explain earlier observations that TNA hydridizes more stably with RNA than with DNA and that RNA constitutes the better template for ligating TNA fragments.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1008784
- Journal Information:
- Angew. Chem. Int. Ed., Vol. 42, Issue (47) ; 2003; ISSN 1433-7851
- Country of Publication:
- United States
- Language:
- ENGLISH
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