Molecular recognition of nitrated fatty acids by PPAR[gamma]
- Pitt
Peroxisome proliferator activated receptor-{gamma} (PPAR{gamma}) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR{gamma} ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR{gamma}. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR{gamma} discrimination of various naturally occurring fatty acid derivatives.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1007097
- Journal Information:
- Nat. Struct. Mol. Biol., Vol. 15, Issue (8) ; 08, 2008; ISSN 1545-9993
- Country of Publication:
- United States
- Language:
- ENGLISH
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