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Title: Rational design of an organometallic glutathione transferase inhibitor

A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor. The mechanism of inhibition was studied using a range of biophysical and biochemical methods.
Authors:
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Publication Date:
OSTI Identifier:
1006135
Resource Type:
Journal Article
Resource Relation:
Journal Name: Angew. Chem. Int. Ed.; Journal Volume: 48; Journal Issue: (21) ; 2009
Research Org:
Argonne National Laboratory (ANL)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; BIOLOGY; CHEMISTRY; DESIGN; GLUTATHIONE; PROTEINS; TARGETS; TRANSFERASES