Identification of a small molecule [beta]-secretase inhibitor that binds without catalytic aspartate engagement
Journal Article
·
· Bioorg. Med. Chem. Lett.
A small molecule inhibitor of beta-secretase with a unique binding mode has been developed. Crystallographic determination of the enzyme-inhibitor complex shows the catalytic aspartate residues in the active site are not engaged in inhibitor binding. This unprecedented binding mode in the field of aspartyl protease inhibition is described.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1005678
- Journal Information:
- Bioorg. Med. Chem. Lett., Vol. 19, Issue (1) ; 01, 2009; ISSN 0960-894X
- Country of Publication:
- United States
- Language:
- ENGLISH
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