skip to main content

Title: Synthesis and SAR of potent LXR agonists containing an indole pharmacophore

A novel series of 1H-indol-1-yl tertiary amine LXR agonists has been designed. Compounds from this series were potent agonists with good rat pharmacokinetic parameters. In addition, the crystal structure of an LXR agonist bound to LXR{alpha} will be disclosed.
Authors:
; ; ; ; ; ; ; ; ; ; ; ;  [1] ;  [1]
  1. (
Publication Date:
OSTI Identifier:
1005519
Resource Type:
Journal Article
Resource Relation:
Journal Name: Bioorg. Med. Chem. Lett.; Journal Volume: 19; Journal Issue: (4) ; 02, 2009
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
ENGLISH
Subject:
36 MATERIALS SCIENCE; AMINES; ARTERIOSCLEROSIS; CRYSTAL STRUCTURE; HORMONES; INDOLES; INFLAMMATION; LIVER; SYNTHESIS