2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode
Journal Article
·
· Bioorg. Med. Chem. Lett.
MK2 is a Ser/Thr kinase of significant interest as an anti-inflammatory drug discovery target. Here we describe the development of in vitro tools for the identification and characterization of MK2 inhibitors, including validation of inhibitor interactions with the crystallography construct and determination of the unique binding mode of 2,4-diaminopyrimidine inhibitors in the MK2 active site.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1002637
- Journal Information:
- Bioorg. Med. Chem. Lett., Vol. 20, Issue (1) ; 01, 2010; ISSN 0960-894X
- Country of Publication:
- United States
- Language:
- ENGLISH
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