Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

Journal Article · Tue May 25 00:00:00 EDT 2010 · Science

DOI:https://doi.org/10.1126/science.1186430· OSTI ID:1002383

Xu, Rui; Ekiert, Damian C; Krause, Jens C; Hai, Rong; Wilson, Ian A ^[1]

---

1. Sinai

The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: USDOE
• OSTI ID: 1002383
• Journal Information: Science, Vol. 328, Issue 04, 2010; ISSN 0193-4511
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

36 MATERIALS SCIENCE
CRYSTAL STRUCTURE
HEMAGGLUTININS
IMMUNITY
INFLUENZA
SWINE
VIRUSES