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Title: Putting the Squeeze on Biology: Biomolecules Under Pressure

Modest pressures encountered in the biosphere (i.e., below a few kbar) have extraordinary effects on biomembranes and proteins. These include pressure denaturation of proteins, dramatic changes in promore »tein-protein association, substrate binding, membrane ion transport, DNA transcription, virus infectivity, and enzyme kinetics. Yet all of the biomaterials involved are highly incompressible. The challenge to the physicist is to understand the structural coupling between these effects and pressure to elucidate the relevant mechanisms. X-ray diffraction studies of membranes and proteins under pressure will be described. It is seen that it is not so much the magnitude of the changes, but rather the differential compressibilities of different parts of the structure that are responsible for effects.« less
Title: Putting the Squeeze on Biology: Biomolecules Under Pressure
Publication Date: 2007-12-12
OSTI Identifier: 987390
Other Number(s): Other: Putting the Squeeze on Biology Biomolecules Under Pressure
Resource Type: Multimedia
Specific Type: Multimedia Presentation
Publisher: Fermilab Colloquia Online: 2000 to the Present Videos of Science Lecture and Presentations from the Colloquium Program at Fermi National Laboratory
Country of Publication: United States
Language: English
Run Time: 0:58:47
System Entry Date: 2016-01-28