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Title: Crystallography Without Crystals: Determining the Structure of Individual Biological Molecules and Nanoparticles

Ever shattered a valuable vase into 10 to the 6th power pieces and tried to reassemble it under a light providing a mean photon count of 10 minus 2 per detector pixel with shot noise? If you can do tmore »hat, you can do single-molecule crystallography. This talk will outline how this can be done in principle. In more technical terms, the talk will describe how the combination of scattering physics and Bayesian algorithms can be used to reconstruct the 3-D diffracted intensity distribution from a collection of individual 2-D diffiraction patterns down to a mean photon count of 10 minus 2 per pixel, the signal level anticipated from the Linac Coherent Light Source, and hence determine the structure of individual macromolecules and nanoparticles.« less
Title: Crystallography Without Crystals: Determining the Structure of Individual Biological Molecules and Nanoparticles
Authors:
Publication Date: 2008-03-05
OSTI Identifier: 987274
DOE Contract Number: ACO2-06CH11357
Other Number(s): Other: 20080305-150047-1
Resource Type: Multimedia
Specific Type: Multimedia Presentation
Resource Relation: Conference: APS Colloquium Series, Advanced Photon Source (APS) at Argonne National Laboratory, Argonne, Illinois (United States), presented on March 05, 2008
Research Org: ANL-APS (Argonne National Laboratory-Advanced Photon Source (United States))
Sponsoring Org: USDOE Office of Science (SC)
Subject: 74 ATOMIC AND MOLECULAR PHYSICS ; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS
Publisher: Advanced Photon Source (APS) Colloquium Series Video Collection
Country of Publication: United States
Language: English
Run Time: 0:44:52
System Entry Date: 2016-01-27