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Title: NERSC & JGI Seek Elusive Proteins for Gene Editing

Abstract

A video just released by the Supercomputing 2017 (SC17) conference shows how biologists at UC Berkeley and the Joint Genome Institute (JGI) – a Department of Energy Office of Science User Facility – are using NERSC, the Office of Science’s primary supercomputing center, to identify a class of enzymes capable of editing out genes responsible for disease. This revolutionary work requires petaflops of computing power to sift through billions of DNA sequences in the JGI data portals to identify proteins like Cas9 that, combined with the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), can “edit” a genome. First discovered by researchers at UC Berkeley, the CRISPR-Cas9 system has the power to permanently correct disease-causing mutations in cells, animal models, and eventually human patients to cure certain types of cancer, cardiovascular disease, sickle cell disease, and retinal degeneration. Since the CRISPR system was first identified in the early 2000s, it has become the most promising technology for treating genetic disease in humans and enabling plants to survive stress caused by pests and the environment. The annual SC17 conference will take place November 12-17 in Denver, Colorado. The over 12,000 attendees from academia, government and industry are leaders in researching and deliveringmore » high performance computing, networking, data storage and analysis in support of scientific discovery. http://sc17.supercomputing.org Producer: Jennifer Boyd, Boyd Productions DP: Damon Hennessey Audio: Richard K. Pooler Score: Michael Bacon Music« less

Authors:
; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1668733
Resource Type:
Multimedia
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 97 MATHEMATICS AND COMPUTING; CRISPR; CRISPR-CAS9; GENE EDITING; NERSC; LARGE SCALE COMPUTING

Citation Formats

Paez-Espino, David, Burstein, David, and Fagnan, Kjiersten. NERSC & JGI Seek Elusive Proteins for Gene Editing. United States: N. p., 2017. Web.
Paez-Espino, David, Burstein, David, & Fagnan, Kjiersten. NERSC & JGI Seek Elusive Proteins for Gene Editing. United States.
Paez-Espino, David, Burstein, David, and Fagnan, Kjiersten. Fri . "NERSC & JGI Seek Elusive Proteins for Gene Editing". United States. https://www.osti.gov/servlets/purl/1668733.
@article{osti_1668733,
title = {NERSC & JGI Seek Elusive Proteins for Gene Editing},
author = {Paez-Espino, David and Burstein, David and Fagnan, Kjiersten},
abstractNote = {A video just released by the Supercomputing 2017 (SC17) conference shows how biologists at UC Berkeley and the Joint Genome Institute (JGI) – a Department of Energy Office of Science User Facility – are using NERSC, the Office of Science’s primary supercomputing center, to identify a class of enzymes capable of editing out genes responsible for disease. This revolutionary work requires petaflops of computing power to sift through billions of DNA sequences in the JGI data portals to identify proteins like Cas9 that, combined with the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), can “edit” a genome. First discovered by researchers at UC Berkeley, the CRISPR-Cas9 system has the power to permanently correct disease-causing mutations in cells, animal models, and eventually human patients to cure certain types of cancer, cardiovascular disease, sickle cell disease, and retinal degeneration. Since the CRISPR system was first identified in the early 2000s, it has become the most promising technology for treating genetic disease in humans and enabling plants to survive stress caused by pests and the environment. The annual SC17 conference will take place November 12-17 in Denver, Colorado. The over 12,000 attendees from academia, government and industry are leaders in researching and delivering high performance computing, networking, data storage and analysis in support of scientific discovery. http://sc17.supercomputing.org Producer: Jennifer Boyd, Boyd Productions DP: Damon Hennessey Audio: Richard K. Pooler Score: Michael Bacon Music},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {12}
}

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