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Title: NERSC & JGI Seek Elusive Proteins for Gene Editing

A video just released by the Supercomputing 2017 (SC17) conference shows how biologists at UC Berkeley and the Joint Genome Institute (JGI) – a Department of Energy Office of Science User Facility – more »are using NERSC, the Office of Science’s primary supercomputing center, to identify a class of enzymes capable of editing out genes responsible for disease. This revolutionary work requires petaflops of computing power to sift through billions of DNA sequences in the JGI data portals to identify proteins like Cas9 that, combined with the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), can “edit” a genome. First discovered by researchers at UC Berkeley, the CRISPR-Cas9 system has the power to permanently correct disease-causing mutations in cells, animal models, and eventually human patients to cure certain types of cancer, cardiovascular disease, sickle cell disease, and retinal degeneration. Since the CRISPR system was first identified in the early 2000s, it has become the most promising technology for treating genetic disease in humans and enabling plants to survive stress caused by pests and the environment. The annual SC17 conference will take place November 12-17 in Denver, Colorado. The over 12,000 attendees from academia, government and industry are leaders in researching and delivering high performance computing, networking, data storage and analysis in support of scientific discovery. http://sc17.supercomputing.org« less
video
Title: NERSC & JGI Seek Elusive Proteins for Gene Editing
Authors:
Publication Date: 2017-12-15
OSTI Identifier: 1469323
DOE Contract Number: AC02-05CH11231
Resource Type: Multimedia
Research Org: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org: USDOE Office of Science (SC)
Subject:
Country of Publication: United States
Language: English
Run Time:
System Entry Date: 2018-09-12