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Title: Mutational Signature Mark Cancer’s Smoking Gun

Abstract

A broad computational study of cancer genome sequences by Los Alamos National Laboratory with the UK’s Wellcome Trust Sanger Institute and other collaborators identifies telltale mutational signatures associated with smoking tobacco. The research demonstrates, for the first time, that smoking increases cancer risk by causing somatic mutations in tissues directly and indirectly exposed to tobacco smoke. The international study was published in the November 4 issue of Science. The analysis shows that tobacco smoking causes mutations leading to cancer by multiple distinct mechanisms, including by damaging DNA in organs and by speeding up a mutational cellular clock.

Authors:
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1333563
Resource Type:
Multimedia
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 97 MATHEMATICS AND COMPUTING; CANCER; TOBACCO SMOKING; MUTATIONAL SIGNATURES; CIGARETTES; SUPERCOMPUTING

Citation Formats

Alexandrov, Ludmil. Mutational Signature Mark Cancer’s Smoking Gun. United States: N. p., 2016. Web.
Alexandrov, Ludmil. Mutational Signature Mark Cancer’s Smoking Gun. United States.
Alexandrov, Ludmil. Thu . "Mutational Signature Mark Cancer’s Smoking Gun". United States. https://www.osti.gov/servlets/purl/1333563.
@article{osti_1333563,
title = {Mutational Signature Mark Cancer’s Smoking Gun},
author = {Alexandrov, Ludmil},
abstractNote = {A broad computational study of cancer genome sequences by Los Alamos National Laboratory with the UK’s Wellcome Trust Sanger Institute and other collaborators identifies telltale mutational signatures associated with smoking tobacco. The research demonstrates, for the first time, that smoking increases cancer risk by causing somatic mutations in tissues directly and indirectly exposed to tobacco smoke. The international study was published in the November 4 issue of Science. The analysis shows that tobacco smoking causes mutations leading to cancer by multiple distinct mechanisms, including by damaging DNA in organs and by speeding up a mutational cellular clock.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {11}
}

Multimedia:

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