Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance
Abstract
ORNL leveraged powerful supercomputing to support research led by University of Oklahoma scientists to identify chemicals that seek out and disrupt bacterial proteins called efflux pumps, known to be a major cause of antibiotic resistance. By running simulations on Titan, the team selected molecules most likely to target and potentially disable the assembly of efflux pumps found in E. coli bacteria cells.
- Authors:
- Publication Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1332726
- Resource Type:
- Multimedia
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION; 59 BASIC BIOLOGICAL SCIENCES; ANTIBIOTIC RESISTANCE; BACTERIAL PROTEINS; FUNGI; VIRUSES; EFFLUX PUMPS; SUPERCOMPUTERS
Citation Formats
Zgurskaya, Helen, and Smith, Jeremy. Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance. United States: N. p., 2016.
Web.
Zgurskaya, Helen, & Smith, Jeremy. Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance. United States.
Zgurskaya, Helen, and Smith, Jeremy. Thu .
"Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance". United States. https://www.osti.gov/servlets/purl/1332726.
@article{osti_1332726,
title = {Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance},
author = {Zgurskaya, Helen and Smith, Jeremy},
abstractNote = {ORNL leveraged powerful supercomputing to support research led by University of Oklahoma scientists to identify chemicals that seek out and disrupt bacterial proteins called efflux pumps, known to be a major cause of antibiotic resistance. By running simulations on Titan, the team selected molecules most likely to target and potentially disable the assembly of efflux pumps found in E. coli bacteria cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Nov 17 00:00:00 EST 2016},
month = {Thu Nov 17 00:00:00 EST 2016}
}