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Title: Project ATHENA Creates Surrogate Human Organ Systems

The development of miniature surrogate human organs, coupled with highly sensitive mass spectrometry technologies, could one day revolutionize the way new drugs and toxic agents are studied. “By demore »veloping this ‘homo minutus,’ we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs,” said Rashi Iyer, a senior scientist at Los Alamos National Laboratory. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is nearing the full integration of four human organ constructs — liver, heart, lung and kidney — each organ component is about the size of a smartphone screen, and the whole ATHENA “body” of interconnected organs will fit neatly on a desk. A new video available on the Los Alamos National Laboratory YouTube channel updates the ATHENA project as it begins to integrate the various organ systems into a single system. Some 40 percent of pharmaceuticals fail their clinical trials and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success. ATHENA is funded by the Defense Threat Reduction Agency (DTRA) and is a collaboration of Los Alamos National Laboratory, Harvard University, Vanderbilt University, Charité Universitätsmedizin, Berlin, Germany, CFD Research Corporation, and the University of California San Francisco.« less
Title: Project ATHENA Creates Surrogate Human Organ Systems
Authors:
Publication Date: 2015-06-15
OSTI Identifier: 1185252
Other Number(s): Other: None
Resource Type: Multimedia
Research Org: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org: USDOE
Subject: 59 BASIC BIOLOGICAL SCIENCES ; LIVER ; LUNG ; KIDNEY ; ORGAN SYSTEM ; BIOLOGY ; ENGINEERING ; BLOOD SURROGATE ; ATHENA ; HEART ; IN VITRO LIVER ; METABOLIZE ; ORGAN
Country of Publication: United States
Language: English
Run Time: 0:04:36
System Entry Date: 2018-06-06