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Title: Multiscale Simulation of Blood Flow in Brain Arteries with an Aneurysm

Abstract

Multi-scale modeling of arterial blood flow can shed light on the interaction between events happening at micro- and meso-scales (i.e., adhesion of red blood cells to the arterial wall, clot formation) and at macro-scales (i.e., change in flow patterns due to the clot). Coupled numerical simulations of such multi-scale flow require state-of-the-art computers and algorithms, along with techniques for multi-scale visualizations.This animation presents results of studies used in the development of a multi-scale visualization methodology. First we use streamlines to show the path the flow is taking as it moves through the system, including the aneurysm. Next we investigate the process of thrombus (blood clot) formation, which may be responsible for the rupture of aneurysms, by concentrating on the platelet blood cells, observing as they aggregate on the wall of the aneurysm.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC); Brown Univ., Providence, RI (United States); Jülich Research Centre (Germany); National Institutes of Health (NIH); National Science Foundation (NSF); Univ. of Tennessee, Knoxville, TN (United States). National Inst. for Computational Science (NICS)
OSTI Identifier:
1082838
DOE Contract Number:
AC02-06CH11357; NIH-R01HL094270; NSF-OCI-0904288
Resource Type:
Multimedia
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 97 MATHEMATICS AND COMPUTING; ANL; BROWN UNIVERSITY; MULTI-SCALE SIMULATIONS; BLOOD FLOW; BLOOD CLOT; THROMBUS; ANEURYSMS; SICKLE CELL ANEMIA; CEREBRAL MALARIA; NEKTAR; DPD-LAMMPS

Citation Formats

Grinberg, Leopold, Morozov, Vitali, Fedosov, Dmitry A., Insley, Joseph, Papka, Michael, Kumaran, Kalyan, and Karniadakis, George. Multiscale Simulation of Blood Flow in Brain Arteries with an Aneurysm. United States: N. p., 2013. Web.
Grinberg, Leopold, Morozov, Vitali, Fedosov, Dmitry A., Insley, Joseph, Papka, Michael, Kumaran, Kalyan, & Karniadakis, George. Multiscale Simulation of Blood Flow in Brain Arteries with an Aneurysm. United States.
Grinberg, Leopold, Morozov, Vitali, Fedosov, Dmitry A., Insley, Joseph, Papka, Michael, Kumaran, Kalyan, and Karniadakis, George. Wed . "Multiscale Simulation of Blood Flow in Brain Arteries with an Aneurysm". United States. https://www.osti.gov/servlets/purl/1082838.
@article{osti_1082838,
title = {Multiscale Simulation of Blood Flow in Brain Arteries with an Aneurysm},
author = {Grinberg, Leopold and Morozov, Vitali and Fedosov, Dmitry A. and Insley, Joseph and Papka, Michael and Kumaran, Kalyan and Karniadakis, George},
abstractNote = {Multi-scale modeling of arterial blood flow can shed light on the interaction between events happening at micro- and meso-scales (i.e., adhesion of red blood cells to the arterial wall, clot formation) and at macro-scales (i.e., change in flow patterns due to the clot). Coupled numerical simulations of such multi-scale flow require state-of-the-art computers and algorithms, along with techniques for multi-scale visualizations.This animation presents results of studies used in the development of a multi-scale visualization methodology. First we use streamlines to show the path the flow is taking as it moves through the system, including the aneurysm. Next we investigate the process of thrombus (blood clot) formation, which may be responsible for the rupture of aneurysms, by concentrating on the platelet blood cells, observing as they aggregate on the wall of the aneurysm.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {4}
}

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