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Title: FEN1 protein with and without DNA

Abstract

The FEN1 protein is especially important during replication of the DNA lagging strand, where it is needed to trim "flaps" of single-strand DNA and prepare them for rejoining. FEN1 and its superfamily are also important in many forms of DNA repair. How FEN1 works only became apparent from crystallography of its structure bound to DNA. The presence of DNA appears to induce a transition from disorder to order that precisely positions and prepares the junction.

Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1046781
Resource Type:
Multimedia
Country of Publication:
United States
Language:
English
Subject:
74 ATOMIC AND MOLECULAR PHYSICS; 59 BASIC BIOLOGICAL SCIENCES; FEN1; PROTEIN STRUCTURE; DNA; CRYSTALLOGRAPHY; JUNCTION

Citation Formats

None. FEN1 protein with and without DNA. United States: N. p., 2011. Web.
None. FEN1 protein with and without DNA. United States.
None. Sat . "FEN1 protein with and without DNA". United States. https://www.osti.gov/servlets/purl/1046781.
@article{osti_1046781,
title = {FEN1 protein with and without DNA},
author = {None},
abstractNote = {The FEN1 protein is especially important during replication of the DNA lagging strand, where it is needed to trim "flaps" of single-strand DNA and prepare them for rejoining. FEN1 and its superfamily are also important in many forms of DNA repair. How FEN1 works only became apparent from crystallography of its structure bound to DNA. The presence of DNA appears to induce a transition from disorder to order that precisely positions and prepares the junction.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {1}
}

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