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Title: FEN1 protein with and without DNA

The FEN1 protein is especially important during replication of the DNA lagging strand, where it is needed to trim "flaps" of single-strand DNA and prepare them for rejoining. FEN1 and its superfamily more »are also important in many forms of DNA repair. How FEN1 works only became apparent from crystallography of its structure bound to DNA. The presence of DNA appears to induce a transition from disorder to order that precisely positions and prepares the junction.« less
Title: FEN1 protein with and without DNA
Publication Date: 2011-01-01
OSTI Identifier: 1046781
Resource Type: Multimedia
Research Org: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org: USDOE
Subject: 74 ATOMIC AND MOLECULAR PHYSICS ; 59 BASIC BIOLOGICAL SCIENCES ; FEN1 ; PROTEIN STRUCTURE ; DNA ; CRYSTALLOGRAPHY ; JUNCTION
Country of Publication: United States
Language: English
Run Time: 0:00:13
System Entry Date: 2018-05-10