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Title: Using Synchrotron Radiation and Electron Microscopy to Map the Huge Structural Changes that Occur in Viruses During Their Life Cycle

The crystallographic techniques for structure determination of proteins and neucleic acids at near atomic resolution using synchrotron X-radiation has become almost automatic. However the limits of thmore »is procedure are determined by the availability of crystals. As the size and complexity of the molecular assemblies being studied increases, the likelihood of growing useful crystals diminishes. Cryo electron microscopy and tomography have extended the range of biological objects that can be determined at near atomic resolution. Furthermore it is now becoming apparent that the function of the molecular assemblies most often requires very large conformational changes that could never be contained within a crystal, Examples will be presented of the structural changes that occur in viruses as they assembly and prepare to infect new cells.« less
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Title: Using Synchrotron Radiation and Electron Microscopy to Map the Huge Structural Changes that Occur in Viruses During Their Life Cycle
Authors:
Publication Date: 2011-09-07
OSTI Identifier: 1042459
DOE Contract Number: DE-ACO2-06CH11357
Resource Type: Multimedia
Resource Relation: Conference: APS Colloquium Series, Advanced Photon Source (APS) at Argonne National Laboratory, Argonne, Illinois (United States), presented on September 7, 2011
Research Org: ANL (Argonne National Laboratory (ANL), Argonne, IL (United States))
Sponsoring Org: USDOE Office of Science (SC)
Subject: 60 APPLIED LIFE SCIENCES ; 59 BASIC BIOLOGICAL SCIENCES ; ANTIFERROMAGNETIC MATERIALS ; CHARGE CARRIERS ; CHARGE DENSITY ; COPPER COMPOUNDS ; COPPER IONS ; CUPRATES ; DIFFRACTION ; DOMAIN STRUCTURE ; DOPED MATERIALS ; ELECTRONIC STRUCTURE ; LAYERS ; KINETIC ENERGY ; OXIDES ; SEGREGATION ; SPIN ; SUPERCONDUCTIVITY ; HIGH-TC SUPERCONDUCTORS ; Viruses ; Synchroton Radiation
Country of Publication: United States
Language: English
Run Time: 0:55:08
System Entry Date: 2016-01-28