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Title: Genetic Differences Between Great Apes and Humans: Implications for Human Evolution

When considering protein sequences, humans are 99-100% identical to chimpanzees and bonobos, our closest evolutionary relatives. The evolution of humans (and the unique features of our species) from amore » common ancestor with these great apes involved many steps, influenced by interactions amongst factors of genetic, developmental, ecological, microbial, climatic, behavioral, cultural and social origin. The genetic factors can be approached by direct comparisons of human and great ape genomes, genes and gene products, and by elucidating biochemical and biological consequences of the differences. We have discovered multiple genetic and biochemical differences between humans and great apes, particularly in relationship to a family of cell surface molecules called sialic acids. These differences have implications for the human condition, ranging from susceptibility or resistance to microbial pathogens; effects on endogenous receptors in the immune system; potential effects on placental signaling; the expression of oncofetal antigens in cancers; consequences of dietary intake of animal foods; and the development of the mammalian brain. This talk will provide an overview of these and other genetic differences between humans and great apes, with attention to differences potentially relevant to the evolution of humans.« less
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Title: Genetic Differences Between Great Apes and Humans: Implications for Human Evolution
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Publication Date: 2004-03-17
OSTI Identifier: 1016520
DOE Contract Number: AC02-07CH11359
Other Number(s): TRN: US201204%%368
Resource Type: Multimedia
Resource Relation: Conference: Fermilab Colloquia, Fermi National Accelerator Laboratory (FNAL), Batvia, Illinois (United States), presented on March 17, 2004
Research Org: FNAL (Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States))
Sponsoring Org: USDOE Office of Science (SC)
Subject: 59 BASIC BIOLOGICAL SCIENCES ; 60 APPLIED LIFE SCIENCES ; ANIMALS ; ANTIGENS ; APES ; BRAIN ; GENES ; GENETICS ; ORIGIN ; PATHOGENS ; PROTEINS ; SIALIC ACID
Country of Publication: United States
Language: English
Run Time: 0:54:48
System Entry Date: 2016-01-27