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Title: Genomics: Looking at Life in New Ways

The availability of complete or nearly complete mouse, human, and rat genomes (in addition to those from many other species) has resulted in a series of new and powerful opportunities to apply the tecmore »hnologies and approaches developed for large-scale genome sequencing to the study of disease. New approaches to biological problems are being explored that involve concepts from computer science such as systems theory and modern large scale computing techniques. A recent project at Celera Genomics involved sequencing protein coding regions from several humans and a chimpanzee. Computational models of evolutionary divergence enabled us to identify genes with unique evolutionary signatures. These genes give us some insight into features that may be uniquely human. The laboratory mouse and rat have long been favorite mammalian models of human disease. Integrated approaches to the study of disease that combine genetics, DNA sequence analysis, and careful analysis of phenotype at a molecular level are becoming more common and powerful. In addition, evaluation of the variation inherent in normal populations is now being used to build networks to describe heart function based on the interaction of multiple phenotypes in randomized populations using a factorial design.« less
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Title: Genomics: Looking at Life in New Ways
Authors:
Publication Date: 2003-10-22
OSTI Identifier: 1016412
DOE Contract Number: AC02-07CH11359
Other Number(s): TRN: US201204%%445
Resource Type: Multimedia
Resource Relation: Conference: Fermilab Colloquia, Fermi National Accelerator Laboratory (FNAL), Batvia, Illinois (United States), presented on October 22, 2003
Research Org: FNAL (Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States))
Sponsoring Org: USDOE Office of Science (SC)
Subject: 59 BASIC BIOLOGICAL SCIENCES ; 60 APPLIED LIFE SCIENCES ; AVAILABILITY ; COMPUTERS ; DESIGN ; DISEASES ; DNA ; EVALUATION ; GENES ; GENETICS ; PHENOTYPE ; PROTEINS ; STRUCTURAL CHEMICAL ANALYSIS
Country of Publication: United States
Language: English
Run Time: 0:55:36
System Entry Date: 2016-01-27