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Title: Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

Abstract

Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

Authors:
 [1]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division; Children’s Hospital Oakland Research Inst. (CHORI), Oakland, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
OSTI Identifier:
1009104
DOE Contract Number:
AC02-05CH11231
Resource Type:
Multimedia
Resource Relation:
Conference: Summer Lecture Series, Lawrence Berkeley National Laboratory, Berkeley, California (United States), presented on June 27, 2007
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; ADULTS; AMINO ACID SEQUENCE; BRAIN; GLIOMAS; IN VITRO; LIPIDS; LIPOPROTEINS; NEOPLASMS; PEPTIDES; TARGETS; Lipoproteins; Lipoprotein (LDL) Particles; Glioblastoma Multiforme; Cancer; Tumor Cells

Citation Formats

Forte, Trudy. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series). United States: N. p., 2007. Web.
Forte, Trudy. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series). United States.
Forte, Trudy. Wed . "Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)". United States. https://www.osti.gov/servlets/purl/1009104.
@article{osti_1009104,
title = {Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)},
author = {Forte, Trudy},
abstractNote = {Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {6}
}

Multimedia: