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Title: Is Overeating Behavior Similar to Drug Addiction? (427th Brookhaven Lecture)

The increasing number of obese individuals in the U.S. and other countries world-wide adds urgency to the need to understand the mechanisms underlying pathological overeating. Research by the speaker more »and others at Brookhaven National Laboratory and elsewhere is compiling evidence that the brain circuits disrupted in obesity are similar to those involved in drug addiction. Using positron emission tomography (PET), the speaker and his colleagues have implicated brain dopamine in the normal and the pathological intake of food by humans. During the 427th Brookhaven Lecture, speaker will review the findings and implications of PET studies of obese subjects and then compare them to PET research involving drug-addicted individuals. For example, in pathologically obese subjects, it was found that reductions in striatal dopamine D2 receptors are similar to those observed in drug-addicted subjects. The speaker and his colleagues have postulated that decreased levels of dopamine receptors predisposed subjects to search for strongly rewarding reinforcers, be it drugs for the drug-addicted or food for the obese, as a means to compensate for decreased sensitivity of their dopamine-regulated reward circuits. As the speaker will summarize, multiple but similar brain circuits involved in reward, motivation, learning and inhibitory control are disrupted both in drug addiction and obesity, resulting in the need for a multimodal approach to the treatment of obesity.« less
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Title: Is Overeating Behavior Similar to Drug Addiction? (427th Brookhaven Lecture)
Authors:
Publication Date: 2007-09-27
OSTI Identifier: 1005177
DOE Contract Number: AC02-98CH10886
Other Number(s): TRN: US1104093
Resource Type: Multimedia
Resource Relation: Conference: Brookhaven Lecture Series: 1960 - Present, Lecture presented at Brookhaven National Laboratory, Upton, New York (United States) on September 26, 2007
Research Org: BNL (Brookhaven National Laboratory (BNL), Upton, NY (United States))
Sponsoring Org: USDOE Office of Science (SC)
Subject: 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS ; BNL ; BRAIN ; DOPAMINE ; FOOD ; LEARNING ; METABOLIC DISEASES ; POSITRONS ; SENSITIVITY ; TOMOGRAPHY
Country of Publication: United States
Language: English
Run Time: 0:47:20
System Entry Date: 2016-01-27