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Title: Shining Light on the Cause of Alzheimer's Disease (411th Brookhaven Lecture)

Alzheimer’s disease is a progressive brain disorder that gradually destroys a person’s memory and ability to learn, reason, communicate and carry out daily activities. An estimated 4.5 million Americamore »ns have it, a number that is expected to triple over the next 50 years. Today, one in ten people aged 65 and half of people over 85 are affected. The cause of Alzheimer’s disease is thought to involve the formation of “plaques” — tiny aggregates of a naturally occurring, but misfolded or misshapen protein — in the brain. Recently, the formation of these plaques has been associated with the binding of metal ions such as iron, copper, and zinc. Yet the function of these metal ions and the misfolded proteins in the disease process is not well understood. Now, synchrotron infrared and x-ray microscopes are used to image the protein structure and metal content in the Alzheimer’s-affected brain tissue, providing a better understanding of how the disease occurs and potential ways of preventing it in the future.« less
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Title: Shining Light on the Cause of Alzheimer's Disease (411th Brookhaven Lecture)
Authors:
Publication Date: 2006-01-18
OSTI Identifier: 1002664
DOE Contract Number: AC02-98CH10886
Other Number(s): TRN: US201117%%414
Resource Type: Multimedia
Resource Relation: Conference: Brookhaven Lecture Series 1960 to the Present, Brookhaven National Laboratory, Upton, New York, presented on January 18, 2006
Research Org: BNL (Brookhaven National Laboratory (BNL), Upton, NY (United States))
Sponsoring Org: USDOE Office of Science (SC)
Subject: 59 BASIC BIOLOGICAL SCIENCES ; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE ; BNL ; BRAIN ; COPPER ; DISEASES ; IRON ; MICROSCOPES ; PROTEIN STRUCTURE ; PROTEINS ; SYNCHROTRONS ; ZINC
Country of Publication: United States
Language: English
Run Time: 1:05:17
System Entry Date: 2016-01-27