Carotenoids promote lateral packing and condensation of lipid membranes
Abstract
Carotenoids are pigment molecules that protect biomembranes against degradation and may be involved in the formation of functional bacterial membrane microdomains. Little is known on whether different types of carotenoids have different effects on the membrane or if there is any concentration dependence of these effects. Here, we present results from molecular dynamics simulations of phospholipid bilayers containing different amounts of either β-carotene or zeaxanthin. Both β-carotene and zeaxanthin show the ability to laterally condense the membrane lipids and reduce their inter-leaflet interactions. With increasing concentrations, both carotenoids increase the bilayer thickness and rigidity. The results reveal that carotenoids have similar effects to cholesterol on regulating the behavior of fluid-phase membranes, suggesting that they could function as sterol substitutes and confirming their potential role in the formation of functional membrane domains.
- Authors:
-
[1];
[3];
[4]
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Berry College, Mt. Berry, GA (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Oregon Health and Science Univ., Portland, OR (United States); The Ohio State Univ., Columbus, OH (United States)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division; USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1787928
- Alternate Identifier(s):
- OSTI ID: 1630220
- Grant/Contract Number:
- AC05-00OR22725; AC02-05CH11231; FWP ERKP752
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Physical Chemistry Chemical Physics. PCCP
- Additional Journal Information:
- Journal Volume: 22; Journal Issue: 21; Journal ID: ISSN 1463-9076
- Publisher:
- Royal Society of Chemistry
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Mostofian, Barmak, Johnson, Quentin R., Smith, Jeremy C., and Cheng, Xiaolin. Carotenoids promote lateral packing and condensation of lipid membranes. United States: N. p., 2020.
Web. doi:10.1039/d0cp01031f.
Mostofian, Barmak, Johnson, Quentin R., Smith, Jeremy C., & Cheng, Xiaolin. Carotenoids promote lateral packing and condensation of lipid membranes. United States. https://doi.org/10.1039/d0cp01031f
Mostofian, Barmak, Johnson, Quentin R., Smith, Jeremy C., and Cheng, Xiaolin. Mon .
"Carotenoids promote lateral packing and condensation of lipid membranes". United States. https://doi.org/10.1039/d0cp01031f. https://www.osti.gov/servlets/purl/1787928.
@article{osti_1787928,
title = {Carotenoids promote lateral packing and condensation of lipid membranes},
author = {Mostofian, Barmak and Johnson, Quentin R. and Smith, Jeremy C. and Cheng, Xiaolin},
abstractNote = {Carotenoids are pigment molecules that protect biomembranes against degradation and may be involved in the formation of functional bacterial membrane microdomains. Little is known on whether different types of carotenoids have different effects on the membrane or if there is any concentration dependence of these effects. Here, we present results from molecular dynamics simulations of phospholipid bilayers containing different amounts of either β-carotene or zeaxanthin. Both β-carotene and zeaxanthin show the ability to laterally condense the membrane lipids and reduce their inter-leaflet interactions. With increasing concentrations, both carotenoids increase the bilayer thickness and rigidity. The results reveal that carotenoids have similar effects to cholesterol on regulating the behavior of fluid-phase membranes, suggesting that they could function as sterol substitutes and confirming their potential role in the formation of functional membrane domains.},
doi = {10.1039/d0cp01031f},
journal = {Physical Chemistry Chemical Physics. PCCP},
number = 21,
volume = 22,
place = {United States},
year = {Mon May 11 00:00:00 EDT 2020},
month = {Mon May 11 00:00:00 EDT 2020}
}
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Molecular Simulation Study of Structural and Dynamic Properties of Mixed DPPC/DPPE Bilayers
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The Condensing Effect of Cholesterol in Lipid Bilayers
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