Enhanced Tooth Structure Via Silver Microwires Following Treatment with 38 Percent Silver Diamine Fluoride.

Seto, Jong; Horst, Jeremy A.; Parkinson, Dilworth Y.; Frachella, John C.; DeRisi, Joseph L.

Title: Enhanced Tooth Structure Via Silver Microwires Following Treatment with 38 Percent Silver Diamine Fluoride.

Full Record
Other Related Research

Abstract

The American Academy of Pediatric Dentistry guidelines recommend treatment of primary teeth with 38 percent silver diamine fluoride (SDF) as a noninvasive option to arrest active dental caries lesions. A significant outcome of SDF treatment are lesions that clinically harden and become more resistant to further decay. Many practicing dentists believe that this increased hardening is due to the reaction of silver and fluoride with carious dentin. The purpose of this study was to focus on the structural and chemical effects of silver diamine fluoride treatment on the native tooth. In SDF-treated cavitated dentin lesions in teeth subsequently extracted for orthodontic reasons, the authors observed continuous, filamentous silver densities formed in situ from 50 to 2,100 μm in length and 0.25 to 7.0 μm in diameter using high-resolution synchrotron X-ray microcomputer tomography and field emission scanning electron microscopy. These "microwires" fill voids in the lesion caused by disease and permeate through surrounding dentinal tubules. Spectroscopy confirmed that the chemical composition of the observed microwires is predominantly silver. These observations suggest mechanistic explanations for the structural reinforcement of carious dentin in addition to remineralization. It is hypothesized that silver diamine fluoride may achieve its antimicrobial functions by biochemical interactions and throughmore »« less

Authors:

Seto, Jong ^[1]; Horst, Jeremy A. ^[2]; Parkinson, Dilworth Y. ^[3]; Frachella, John C. ^[4]; DeRisi, Joseph L. ^[5]

Univ. of California, San Francisco, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry
Univ. of California, San Francisco, CA (United States); Univ. of Washington, Seattle, WA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)
Bluefish Dental & Orthodontics, Bend, OR (United States)
Univ. of California, San Francisco, CA (United States); Chan-Zuckerberg BioHub, San Francisco, CA (United States)

Publication Date:: Fri May 01 00:00:00 EDT 2020

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:: 1760245

Grant/Contract Number:: AC02-05CH11231; T32-DE007306

Resource Type:: Accepted Manuscript

Journal Name:: Pediatric Dentistry

Additional Journal Information:: Journal Volume: 42; Journal Issue: 3; Journal ID: ISSN 0164-1263

Publisher:: American Academy of Pediatric Dentistry

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; biological materials; caries treatment; remineralization; silver diamine fluoride; synchrotron x-ray micro-computed tomography

Citation Formats


                    Seto, Jong, Horst, Jeremy A., Parkinson, Dilworth Y., Frachella, John C., and DeRisi, Joseph L. Enhanced Tooth Structure Via Silver Microwires Following Treatment with 38 Percent Silver Diamine Fluoride..  United States: N. p., 2020. 
Web.

Copy to clipboard


                    Seto, Jong, Horst, Jeremy A., Parkinson, Dilworth Y., Frachella, John C., & DeRisi, Joseph L. Enhanced Tooth Structure Via Silver Microwires Following Treatment with 38 Percent Silver Diamine Fluoride..  United States.

Copy to clipboard


                    Seto, Jong, Horst, Jeremy A., Parkinson, Dilworth Y., Frachella, John C., and DeRisi, Joseph L. Fri .  
"Enhanced Tooth Structure Via Silver Microwires Following Treatment with 38 Percent Silver Diamine Fluoride.".  United States.  https://www.osti.gov/servlets/purl/1760245.

Copy to clipboard


                    
@article{osti_1760245,

  title        = {Enhanced Tooth Structure Via Silver Microwires Following Treatment with 38 Percent Silver Diamine Fluoride.},

  author       = {Seto, Jong and Horst, Jeremy A. and Parkinson, Dilworth Y. and Frachella, John C. and DeRisi, Joseph L.},

  abstractNote = {The American Academy of Pediatric Dentistry guidelines recommend treatment of primary teeth with 38 percent silver diamine fluoride (SDF) as a noninvasive option to arrest active dental caries lesions. A significant outcome of SDF treatment are lesions that clinically harden and become more resistant to further decay. Many practicing dentists believe that this increased hardening is due to the reaction of silver and fluoride with carious dentin. The purpose of this study was to focus on the structural and chemical effects of silver diamine fluoride treatment on the native tooth. In SDF-treated cavitated dentin lesions in teeth subsequently extracted for orthodontic reasons, the authors observed continuous, filamentous silver densities formed in situ from 50 to 2,100 μm in length and 0.25 to 7.0 μm in diameter using high-resolution synchrotron X-ray microcomputer tomography and field emission scanning electron microscopy. These "microwires" fill voids in the lesion caused by disease and permeate through surrounding dentinal tubules. Spectroscopy confirmed that the chemical composition of the observed microwires is predominantly silver. These observations suggest mechanistic explanations for the structural reinforcement of carious dentin in addition to remineralization. It is hypothesized that silver diamine fluoride may achieve its antimicrobial functions by biochemical interactions and through its inherent ability to integrate into the native tooth structure.},

  doi          = {},

  journal      = {Pediatric Dentistry},

  number       = 3,

  volume       = 42,

  place        = {United States},

  year         = {Fri May 01 00:00:00 EDT 2020},

  month        = {Fri May 01 00:00:00 EDT 2020}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (DOE)

Publisher's Version of Record

The DOI is not currently available

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Enhanced Tooth Structure Via Silver Microwires Following Treatment with 38 Percent Silver Diamine Fluoride.

Journal Article Seto, Jong ; Horst, Jeremy A. ; Parkinson, Dilworth Y. ; ... - Pediatric Dentistry (Online)

Purpose: American Academy of Pediatric Dentistry guidelines recommend treatment of primary teeth with 38 percent silver diamine fluoride (SDF) as a noninvasive option to arrest active dental caries lesions. A significant outcome of SDF treatment are lesions that clinically harden and become more resistant to further decay. Many practicing dentists believe that this increased hardening is due to the reaction of silver and fluoride with carious dentin. The purpose of this study was to focus on the structural and chemical effects of silver diamine fluoride treatment on the native tooth. Methods: In SDF-treated cavitated dentin lesions in teeth subsequently extractedmore »« less
Full Text Available
3D exemplar-based random walks for tooth segmentation from cone-beam computed tomography images

Journal Article Pei, Yuru ; Ai, Xingsheng ; Zha, Hongbin ; ... - Medical Physics

Purpose: Tooth segmentation is an essential step in acquiring patient-specific dental geometries from cone-beam computed tomography (CBCT) images. Tooth segmentation from CBCT images is still a challenging task considering the comparatively low image quality caused by the limited radiation dose, as well as structural ambiguities from intercuspation and nearby alveolar bones. The goal of this paper is to present and discuss the latest accomplishments in semisupervised tooth segmentation with adaptive 3D shape constraints. Methods: The authors propose a 3D exemplar-based random walk method of tooth segmentation from CBCT images. The proposed method integrates semisupervised label propagation and regularization by 3Dmore »« less
https://doi.org/10.1118/1.4960364
The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale

Journal Article Bertassoni, Luiz E ; Orgel, Joseph P.R. ; Antipova, Olga ; ... - Acta Biomater.

The prevention and treatment of dental caries are major challenges occurring in dentistry. The foundations for modern management of this dental disease, estimated to affect 90% of adults in Western countries, rest upon the dependence of ultrafine interactions between synthetic polymeric biomaterials and nanostructured supramolecular assemblies that compose the tooth organic substrate. Research has shown, however, that this interaction imposes less than desirable long-term prospects for current resin-based dental restorations. Here we review progress in the identification of the nanostructural organization of the organic matrix of dentin, the largest component of the tooth structure, and highlight aspects relevant to understatingmore »« less
https://doi.org/10.1016/j.actbio.2012.02.022
Characterization of enamel caries lesions in rat molars using synchrotron X-ray microtomography

Journal Article Free, R. D. ; DeRocher, K. ; Stock, S. R. ; ... - Journal of Synchrotron Radiation (Online)

Dental caries is a ubiquitous infectious disease with a nearly 100% lifetime prevalence. Rodent caries models are widely used to investigate the etiology, progression and potential prevention or treatment of the disease. To explore the suitability of these models for deeper investigations of intact surface zones during enamel caries, the structures of early-stage carious lesions in rats were characterized and compared with previous reports on white spot enamel lesions in humans. Synchrotron X-ray microcomputed tomography non-destructively mapped demineralization in carious rat molar specimens across a range of caries severity, identifying 52 lesions across the 30 teeth imaged. Of these lesions,more »« less
https://doi.org/10.1107/S1600577517008724
Toward accurate tooth segmentation from computed tomography images using a hybrid level set model

Journal Article Gan, Yangzhou ; Zhao, Qunfei ; Xia, Zeyang ; ... - Medical Physics

Purpose: A three-dimensional (3D) model of the teeth provides important information for orthodontic diagnosis and treatment planning. Tooth segmentation is an essential step in generating the 3D digital model from computed tomography (CT) images. The aim of this study is to develop an accurate and efficient tooth segmentation method from CT images. Methods: The 3D dental CT volumetric images are segmented slice by slice in a two-dimensional (2D) transverse plane. The 2D segmentation is composed of a manual initialization step and an automatic slice by slice segmentation step. In the manual initialization step, the user manually picks a starting slicemore »« less
https://doi.org/10.1118/1.4901521

Similar Records